Ohio Sinus Institute has always been active in cutting edge clinical research and has been involved in a number of research projects over the years. In 2005, a new technology, balloon sinus dilation was introduced by a California based company and Dr. Karanfilov was invited to perform the first case in Ohio and served as a contributing author of the landmark clinical study that assessed the safety and effectiveness of this technology. As the techniques evolved and were refined, balloon dilation of blocked sinus passageways were introduced for office use. We performed our first in office balloon sinuplasty in 2007 and then joined a national clinical trial ORIOS I to test the feasibility of performing the procedure under local anesthesia in the office setting. Dr. Karanfilov was then invited to be the primary author for the largest clinical trial to date, greater than 200 patients, to further refine and report on the results of office based balloon sinus dilation for chronic sinusitis sufferers. This study was presented at the national annual American Rhinologic Society Meeting and was published in the highly respected peer reviewed journal, International Forum of Allergy and Rhinology in 2013.